Acute and 4-week daily allulose intake differentially affect postprandial GLP-1 and PYY responses in healthy adults

OverviewThis repository contains the complete analysis code, processed datasets, and documentation for the LisA trial (Low-calorie Sweetener Intervention Study Allulose), a longitudinal crossover intervention study comparing metabolic effects of acute and 4-week long daily allulose intake versus aspartame in healthy adults. Repository Structure: * Allulose_Intervention_Data_and_Code.Rproj: RStudio project file for environment and path management. * 01_LisA_GH_Satiety_Script.qmd / .pdf: Code and rendered reports for gastrointestinal hormones and satiety parameters. * 02_LisA_OGTT_Script.qmd / .pdf: Code and rendered reports for the oral glucose tolerance test (OGTT) evaluations. * 03_LisA_CGM_Script.qmd / .pdf: Code and rendered reports for continuous glucose monitoring (CGM) data. * 04_LisA_BW_BIA_Script.qmd / .pdf: Code and rendered reports for body weight and bioelectrical impedance analysis (BIA). * README.md: Detailed documentation covering variable dictionaries, session info, and pipeline execution instructions. * DATA_LICENSE.txt * CODE_LICENSE.txt * dataDir/: Contains the anonymized and processed datasets required to run the analysis scripts. * 01_Gut_Hormones_and_satiety.xlsx * 02_OGTT.xlsx * 03_CGM.xlsx * 04_Anthropometry_BIA.xlsx Software & ReproducibilityAll analyses were performed in R using Quarto (.qmd) documents. The repository is structured to ensure full computational reproducibility in compliance with Open Science standards. Package dependencies and session details are documented within the individual reports. Related Publication