The Cancer Genome Atlas Lung Squamous Cell Carcinoma Collection

<p>The Cancer Genome Atlas Lung Squamous Cell Carcinoma (TCGA-LUSC) data collection is part of a larger effort to build a research community focused on connecting cancer phenotypes to genotypes by providing clinical images matched to subjects from <a href="http://cancergenome.nih.gov/">The Cancer Genome Atlas (TCGA)</a>. Clinical, genetic, and pathological data resides in the <a href="https://portal.gdc.cancer.gov/exploration?filters=%7B%22op%22%3A%22and%22%2C%22content%22%3A%5B%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.project.project_id%22%2C%22value%22%3A%5B%22TCGA-LUSC%22%5D%7D%7D%5D%7D">Genomic Data Commons (GDC) Data Portal</a> while the radiological data is stored on The Cancer Imaging Archive (TCIA). </p><p>Matched TCGA patient identifiers allow researchers to explore the TCGA/TCIA databases for correlations between tissue genotype, radiological phenotype and patient outcomes.  Tissues for TCGA were collected from many sites all over the world in order to reach their accrual targets, usually around 500 specimens per cancer type.  For this reason the image data sets are also extremely heterogeneous in terms of scanner modalities, manufacturers and acquisition protocols.  In most cases the images were acquired as part of routine care and not as part of a controlled research study or clinical trial. </p><h3>CIP TCGA Radiology Initiative</h3><p>Imaging Source Site (ISS) Groups are being populated and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, ISS groups are given the opportunity to publish a marker paper for a given cancer type per the guidelines in the table above. This opportunity will generate increased participation in building these multi-institutional data sets as they become an open community resource.  Learn more about the <a href="/display/Public/TCGA+Lung+Phenotype+Research+Group">TCGA Lung Phenotype Research Group</a>.</p>

《癌症基因组图谱肺癌鳞状细胞癌（TCGA-LUSC）数据集》系一项旨在构建研究社区的更大努力的一部分，该社区致力于通过提供与《癌症基因组图谱》（TCGA）受试者相匹配的临床图像，将癌症表型与基因型相联系。临床、遗传和病理数据存放在《基因组数据 Commons（GDC）数据门户》（Genomic Data Commons Data Portal）中，而影像学数据则存储在《癌症影像存档》（The Cancer Imaging Archive，TCIA）上。通过匹配的TCGA患者标识符，研究人员能够探索TCGA/TCIA数据库，以研究组织基因型、影像学表型和患者预后之间的相关性。TCGA组织样本来自全球多个地点，以实现其积累目标，通常每种癌症类型约500个样本。因此，图像数据集在扫描器模式、制造商和采集协议方面也极为异质。在大多数情况下，图像作为常规护理的一部分获取，而非作为受控研究或临床试验的一部分。

《CIP TCGA 影像学倡议》

影像来源站点（Imaging Source Site，ISS）组正在由为特定癌症类型向存档提供影像数据的机构参与者填充和管理。参照TCGA分析组，ISS组有机会根据上表中的指南为特定癌症类型发表标记论文。这一机会将促进构建这些多机构数据集的参与度增加，因为它们已成为开放的社区资源。了解更多关于《TCGA 肺部表型研究组》（TCGA Lung Phenotype Research Group）的信息。