RSC and ISW1 Chromatin Remodelers Display Functional and Chromatin-based Promoter Antagonism [nucleosome occupancy]

ISWI-family chromatin remodelers organize nucleosome arrays, while SWI/SNF-family remodelers (RSC) disorganize and eject nucleosomes, implying an antagonism that is largely unexplored in vivoISWI家族染色质重塑因子（ISWI-family chromatin remodelers）可组织核小体阵列，而SWI/SNF家族重塑因子（SWI/SNF-family remodelers，RSC）则会解聚并逐出核小体，这暗示二者间存在拮抗作用，而该拮抗作用在体内的相关研究仍未得到充分探索。