Mutated human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to Niraparib (MK-4827)

Mutated human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to Niraparib (MK-4827) Descriptor: 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide, GLYCEROL, Poly [ADP-ribose] polymerase 2 Authors: Wang, X.Y, Zhou, J, Xu, B.L. Deposit date: 2022-11-30 Release date: 2024-05-01 Last modified: 2025-05-14 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Engaging an engineered PARP-2 catalytic domain mutant to solve the complex structures harboring approved drugs for structure analyses. Bioorg.Chem., 160, 2025