Do 2-year changes in superior frontal gyrus and global brain atrophy affect cognition? Study data

Metabolic alterations to the superior frontal gyrus (SFG) have been linked to cognitive decline and transition from Mild Cognitive Impairment to Alzheimer’s disease (AD). Whether these indicate structural atrophy, which could be screened for at a larger scale using non-invasive structural imaging is unknown. We assessed annual structural MRI scans and cognitive data from 3 consecutive years from 204 participants from the AD Neuroimaging Initiative database (mean age 72.24(8.175) years). We evaluated associations between brain structural changes and performance in the Montreal Cognitive Assessment, Everyday Cognition visuospatial subtest (Ecog Visuospatial) and Functional Assessment Questionnaire. This dataset contains the MATLAB scripts with the analyses, and the results of the data extraction and quantitative image processing (i.e. volumetric measurements).