Evidence for cohesin sliding along budding yeast chromosomes

The ring-shaped cohesin complex is thought to topologically hold sister chromatids together from their synthesis in S-phase until chromosome segregation in mitosis学界普遍认为，环形黏连蛋白复合体（cohesin complex）能够以拓扑方式结合姐妹染色单体（sister chromatids），将二者从S期（S-phase）的合成阶段，一直维系至有丝分裂（mitosis）过程中的染色体分离（chromosome segregation）环节。