3' UTR length and mRNP composition determine endocleavage efficiencies at termination codons. 3' UTR length and mRNP composition determine endocleavage efficiencies at termination codons
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https://www.ncbi.nlm.nih.gov/bioproject/PRJEB7212
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资源简介：
We aimed to study the cleavage sites of nonsense-mediated mRNA decay (NMD) substrates. Therefore, we depleted the major exoribonuclease XRN1 in human cell culture, which degrades the 3' fragments generated by SMG6-mediated endonucleolytic cleavage. Different reporter mRNAs or endogenous NMD targets were investigated and the 3' fragments were cloned, amplified and subsequently subjected to high throughput sequencing.
创建时间：
2014-11-12
