Molecular distinctions between proprioceptors supplying Tibialis anterior (TA) and Gastrocnemius (GS) muscles [RNA-Seq]. Mus musculus

Muscle-specific populations of proprioceptive sensory neurons form selective connections with spinal motor neurons, implying the existence of molecular distinctions between proprioceptor subpopulations. Here, we compare the gene expression profiles of proprioceptors that supply an antagonistic muscle pair functioning at a single hindlimb joint. Overall design: TA and GS muscles in a Pv::YFP reporter line were injected at p0 with ctb-555; retrogradely labeled proprioceptors were manually isolated at p1 and pooled to form 25-30 neuron samples.