Targeted protein degradation is a rapidly exploding drug discovery strategy that uses small molecules to recruit disease-causing proteins for rapid destruction mainly via the ubiquitin–proteasome path
Covalent chemistry coupled with activity-based protein profiling (ABPP) offers a versatile way to discover ligands for proteins in native biological systems. Here, we describe a set of stereo- and reg
Targeted protein degradation is a new paradigm in drug development that promises to overcome limitations of traditional pharmacology. It is based on small molecules that induce proximity of a target p
Supplementary Material 10. Supplementary Table 2. LC-MS/MS processed data of CRBN BioE3 with proteasomal inhibitor bortezomib, with or without NEDDylation inhibitor MLN4924. Gene Ontology analysis of
