TPO stimulation midulates gene expression of iKMT2A-MLLT3 HSPC

Investigate the immediate impact of in vivo exposure to exogenous TPO on gene expression, Overall design: We profiled Evi1highFlt3-LSK iKMT2A-MLLT3 cells after 2 and 5 days on Dox at the single cell level. LT-HSC and MPP1-3 by using a hashtag oligonucleotide and antibody-derived tag labelling strategy for cellular indexing ofoligonucleotide and antibody-derived tag labelling strategy for cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq)