Dataset for the thesis entitled "On the causes and consequences of hypertension"

The data
provided and/or described here facilitate the replication of the findings
detailed in the thesis titled “On the causes and consequences of hypertension”.
The Hong Kong Department of Health Elderly Health Service Cohort was used to
validate and recalibrate a prediction model for all-cause mortality (Chapter
3), and assessment of selection bias (Chapter 4). Publicly available genetic
metadata were obtained to investigate the role of blood pressure on
cardiovascular and longevity (Chapter 5), as well as cancer (Chapter 6), and
also the role of pubertal timing on blood pressure (Chapter 7), growth and sex
hormones (Chapter 8), and finally the men’s phenome in the UK Biobank (Chapter
9).

https://cvd.hugeamp.org/

https://www.ebi.ac.uk/gwas/publications/29227965

https://www.ebi.ac.uk/gwas/publications/32887889

http://www.nealelab.is/uk-biobank

https://zenodo.org/record/4706671#.YcP6jmhBwdX

本数据集所提供及描述的内容，有助于复制论文《论高血压的原因与后果》中所阐述的发现。本研究采用了香港卫生部门老年人健康服务队列，以验证和校准全因死亡率预测模型（第3章），并评估选择偏差（第4章）。此外，通过获取公开可用的遗传元数据，本研究探讨了血压在心血管疾病和长寿（第5章）、癌症（第6章）中的作用，以及青春期时间对血压、生长和性激素（第7章、第8章）的影响，最后分析了英国生物样本库中男性的表型（第9章）。

[https://cvd.hugeamp.org/]
[https://www.ebi.ac.uk/gwas/publications/29227965]
[https://www.ebi.ac.uk/gwas/publications/32887889]
[http://www.nealelab.is/uk-biobank]
[https://zenodo.org/record/4706671#.YcP6jmhBwdX]