Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

We conducted a genome-wide association study (GWAS) with replication in
36,180 Chinese individuals and performed further transancestry
meta-analyses with data from the Psychiatry Genomics Consortium (PGC2).
Approximately 95% of the genome-wide significant (GWS) index alleles (or
their proxies) from the PGC2 study were overrepresented in Chinese
schizophrenia cases, including ∼50% that achieved nominal significance
and ∼75% that continued to be GWS in the transancestry analysis. The
Chinese-only analysis identified seven GWS loci; three of these also
were GWS in the transancestry analyses, which identified 109 GWS loci,
thus yielding a total of 113 GWS loci (30 novel) in at least one of
these analyses. We observed improvements in the fine-mapping resolution
at many susceptibility loci. Our results provide several lines of
evidence supporting candidate genes at many loci and highlight some
pathways for further research. Together, our findings provide novel
insight into the genetic architecture and biological etiology of
schizophrenia.