The role of histone lysine demethylases in a genetically defined subset of clonal hematopoiesis

NIAID Data Ecosystem2026-05-02 收录

克隆性造血

组蛋白去甲基化

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE242099 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2024-08-30

KDM2A-nucleosome structure stabilized by H3K36C-UNC8015 covalent conjugate

染色质结构

组蛋白去甲基化

KDM2A-nucleosome structure stabilized by H3K36C-UNC8015 covalent conjugate Descriptor: DNA (185-MER), FE (III) ION, Histone H2A type 1, ... Authors: Spangler, C.J, Skrajna, A, Foley, C.A, Budziszewski

Protein Data Bank Japan2024-06-12 更新210

KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development

早期胚胎发育表观遗传调控

组蛋白去甲基化

H3K27me3 represses developmental genes at initial embryonic stages. The KDM6 family, comprised of UTX and JMJD3, are the only known proteins that demethylate H3K27me3 and they are hypothesized to cata

NIAID Data Ecosystem70

Genome-wide studies of histone Me2 SWIRM and polyamine oxidase domain homologues of mammalian LSD1. Schizosaccharomyces pombe

组蛋白去甲基化

ChIP-seq分析

In order to gain a more global view of the activity of histone demethylases we report here studies of the two fission yeast SWIRM and polyamine oxidase domain homologues of mammalian LSD1. Consistent

NIAID Data Ecosystem20

Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis

牙周病

组蛋白去甲基化

Periodontal disease (PD) afflicts 46% of Americans with no effective adjunctive therapies available. While most pharmacotherapy for PD targets bacteria, the host immune response is responsible for dri

DataCite Commons2020-08-29 更新110

Effect on gene expression of knock down of Scrambled control or Kdm3b on wild-type or Idh2 R140Q TF-1 cells

克隆性造血

组蛋白甲基化功能

Clonal hematopoiesis (CH) is a common premalignant state in the blood and confers an increased risk of blood cancers and all-cause mortality. Identification of therapeutic targets in CH has been hinde

NIAID Data Ecosystem20

The role of histone lysine demethylases in a genetically defined subset of clonal hematopoiesis

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