Human cytokine antibody array kit (RayBiotech, USA) contending 20 different growth factors/cytokines were used for analysis of protein expression profile in tumor tissue and cells lysate.

G-CSF: colony stimulating factor; PDGF-RA: platelet-derived growth factor receptor, alpha polypeptide; PDGF-AA: platelet-derived growth factor alpha polypeptide; bFGF: fibroblast growth factor (basic); EGF: epidermal growth factor; EGF-R: epidermal growth factor receptor; IGF-I: insulin-like growth factor 1; MMP-9: matrix metallopeptidase 9; SDF-1α: Stromal cell-derived factor 1 alpha; Tie-1: receptor tyrosine kinase of angiopoietin-2; Tie-2: receptor tyrosine kinase of angiopoietin-1; VEGF-A: vascular endothelial growth factor A; VEGF-C: vascular endothelial growth factor C; VEGF-R2: vascular endothelial growth factor receptor 2; VEGF-R3: vascular endothelial growth factor receptor 3. All antibodies are prepared in duplicate. ns: no significant; *not evaluated.Human cytokine antibody array kit (RayBiotech, USA) contending 20 different growth factors/cytokines were used for analysis of protein expression profile in tumor tissue and cells lysate.