Hazard ratios (and 95% CIs) for mortality according to the MR-pro-ADM, CT-pro-ET1 and copeptin levels.

The hazard ratios are displayed for a one-unit increase in the decadic log-transformed (corresponding to a ten-fold increase) of the plasma MR-pro-ADM, CT-pro-ET1 and copeptin concentration. Cardiovascular mortality was considered as sudden death (most probably circulatory or cardiac arrest) and death due to a cardiovascular event or disease (coronary artery disease, hypertensive crisis, stroke, peripheral artery disease).Model 1: adjusted for demographics, hemodynamic and dialysis-specific risk factors.- age.- gender (male).- time on dialysis.- residual diuresis.- shunt flow.- vascular access on study enrolment (fistula, graft or catheter).- systolic and diastolic blood pressure.- interdialytic weight gain.- pooled Kt/V.Model 2: adjusted for all factors associated with mortality (significant difference between deceased and surviving patients).- age.- body mass index.- duration of HD session.- diastolic blood pressure.- secondary hyperparathyroidism (represented by parathormone concentration).- inflammatory status (represented by CRP concentration).- comorbidities: systolic dysfunction (1 = yes), peripheral vascular disease (1 = yes), coronary artery disease (1 = yes), atrial fibrillation (1 = yes).