Small RNA sequencing facilitates quantitative miRNA analysis of fetal and maternal placental tissue in IUGR bovine fetuses. Small RNA sequencing facilitates quantitative miRNA analysis of fetal and maternal placental tissue in IUGR bovine fetuses

Small RNA next generation sequencing and quantitative PCR revealed placental tissue-specific expression of the miR-4321, known to regulate many genes involved in early fetal development. This study also indicated that maternal and fetal components of the placenta respond differently to a deleterious fetal mutation. Overall design: Maternal and fetal placenta samples were collected from cows gestating MIMT1Del/WT fetuses and cows gestating wild-type fetuses terminated on the 94th ± 12 day of pregnancy