Cryo-EM structure of human NaV1.6/beta1/beta2-4,9-anhydro-tetrodotoxin

Cryo-EM structure of human NaV1.6/beta1/beta2-4,9-anhydro-tetrodotoxin Descriptor: (1R,2S,3S,4R,5R,9S,11S,12S,14R)-7-amino-2,4,12-trihydroxy-2-(hydroxymethyl)-10,13,15-trioxa-6,8-diazapentacyclo[7.4.1.1~3,12~.0~5,11~.0~5,14~]pentadec-7-en-8-ium (non-preferred name), 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein type 8 subunit alpha, ... Authors: Li, Y, Jiang, D. Deposit date: 2022-09-24 Release date: 2023-03-08 Last modified: 2025-05-21 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structure of human Na V 1.6 channel reveals Na + selectivity and pore blockade by 4,9-anhydro-tetrodotoxin. Nat Commun, 14, 2023