Additional file 6 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients

Additional file 6: Supplementary Table 4. Genes differentially expressed in female and male, 3xTg-AD and WT mice between ages. Total RNA was isolated from the bulk brain tissue of female and male, 6–24-month-old (oldest age variable), 3xTg-AD and WT mice, and sequenced. Longitudinal differential expression analyses were performed, measuring differences in gene expression of subsequent ages compared to a baseline of 6-months-old (n = 3-4/sex+age+strain) with a negative binomial generalized linear model.