Associations with CIMP-high in colorectal cancer by univariate and multivariate analyses.

Multivariate logistic regression model includes all of the above variables. Note that female, tumor stage, signet ring cells, mucinous feature, KRAS and p53 are not significantly related with CIMP-high after adjusting for other variables. *β-catenin activation is defined as β-catenin score ≥3. The β-catenin score is the sum of nuclear (0, 1+ or 2+), cytoplasmic (0, 1+ or 2+) and membrane (0 or 1+) scores as originally described by Jass et al.[35]. ∧Proximal colon includes cecum to transverse colon, and distal colon includes splenic flexure to rectum. CI, confidence interval; CIMP, CpG island methylator phenotype; LINE-1, long interspersed nucleotide element-1; MSI, microsatellite instability; OR, odds ratio.