A single-nucleus atlas of hippocampus reveals transcriptional alterations underlying developmental sevoflurane neurotoxicity

Neurotoxicity after multiple exposures to general anesthetics is of great concern in pediatric anesthesia. Multiple neonatal exposures to sevoflurane caused behavior and cognitive disorders, but the lack of cell type-specific resource has limited our understanding of its mechanism. Here, we conducted the single-nuclei RNA sequencing (snRNA-seq) study to reveal a cellular atlas of hippocampus during the developmental sevoflurane neurotoxicity compared with the physiological condition.