Age-regulated genes common to humans, rhesus macaques, and mice.

Shown are fold changes (aged to young intensity ratio; minus sign for age-downregulated, no sign for age-upregulated) and statistical q-values (%) derived by Significance Analysis of Microarrays (SAM) as described in Methods. Category I contains genes for which age-related expression changes are conserved, both in terms of significance and direction, across all three species. Category II contains genes in which the direction of the relationship with age changes from mouse to rhesus macaque. Category III contains genes in which the direction of the relationship with age changes between rhesus macaque and human.