Software code, data, and videos for A Mathematical Model for Chemo-mechanically Induced Collective Cell Motility on Planar Elastic Substrates

1) MATLAB CODETwo archives containing Matlab code for simulation with different cases.Displacement for collective cells.zipDisplacement for one motile cell.zipCommon files in all archives and their function:distance.m: A function to compute the strain energy density and the resultant vectors in x and y directions.strain.m: Calculate integration over a specific area.diffusion.m: Calculate the diffusion of the growth factor.Random.m: Calculate the Brownian motion.MCirsqrc.m: Plot cell and growth factor positions.Additional archive-specific files and their function:Archive “Displacement for collective cells.zip”:Growth_Displacement.m: Main code that combines all other functions and calculates cell displacement induced by a growth factor only and combined with mechanical.Rcircles.m: Calculate the initial positions of the cells.Archive “Displacement for one motile cell.zip”:fixed_cell_position.m: Main code that combines all other functions and calculates one motile cell and one stationary cell in chemical and mechanical cues.2) SUPPLEMENTAL VIDEOSVideos showing simulations of cell migration for several cases are reported in manuscript. Video numbers correspond to Figure numbers in the manuscript.Video V3A: Chemically induced migration of 25 cells with growth factor production rate = 60 mol/µm2s and diffusion rate = 179 µm2/sVideo V3B: Chemically induced migration of 25 cells with growth factor production rate = 970 mol/µm2s and diffusion rate = 179 µm2/sVideo V3C: Chemically induced migration of 25 cells with growth factor production rate = 8,000 mol/µm2s and diffusion rate = 179 µm2/sVideo V4A: Chemically induced migration of 25 cells with growth factor production rate = 8,000 mol/µm2s and diffusion rate = 23 µm2/sVideo V4B: Chemically induced migration of 25 cells with growth factor production rate = 8,000 mol/µm2s and diffusion rate = 83 µm2/sVideo V5A: Chemo-mechanically induced migration of 4 cells with growth factor production rate = 60 mol/µm2s and diffusion rate = 179 µm2/sVideo V5B: Chemo-mechanically induced migration of 4 cells with growth factor production rate = 970 mol/µm2s and diffusion rate = 179 µm2/sVideo V5C: Chemo-mechanically induced migration of 4 cells with growth factor production rate = 8,000 mol/µm2s and diffusion rate = 179 µm2/sVideo V6A: Chemo-mechanically induced migration of 4 cells with growth factor production rate = 8,000 mol/µm2s and diffusion rate = 23 µm2/sVideo V6B: Chemo-mechanically induced migration of 4 cells with growth factor production rate = 8,000 mol/µm2s and diffusion rate = 83 µm2/sVideo V7A: Chemo-mechanically induced migration of single-cell with growth factor production rate = 60 mol/µm2s and diffusion rate = 179 µm2/sVideo V7B: Chemo-mechanically induced migration of single-cell with growth factor production rate = 970 mol/µm2s and diffusion rate = 179 µm2/sVideo V7C: Chemo-mechanically induced migration of single-cell with growth factor production rate = 8,000 mol/µm2s and diffusion rate = 179 µm2/sVideo V8A: Chemo-mechanically induced migration of single-cell with growth factor production rate = 8,000 mol/µm2s and diffusion rate = 23 µm2/sVideo V8B: Chemo-mechanically induced migration of single-cell with growth factor production rate = 8,000 mol/µm2s and diffusion rate = 83 µm2/s