Comparison of normal breast epithelium and stroma from reduction and I.D.C. cases

Histologically normal breast epithelium and stroma were laser capture microdissected from breast reduction specimens and from specimens of invasive ductal carcinoma. The objective of the study was to compare normal reduction tissues to tissues adjacent to I.D.C. to determine whether adjacent normal tissues contained expression profiles correlated with characteristics of the primary tumor and to identify markers of normal epithelium and stroma. Keywords: disease state analysis common reference design. 66 samples replicated twice as dye swaps generating 132 arrays.