Single-cell RNA sequencing analysis of Angiotensin II-induced mouse dissecting AAA samples

Dissecting abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by medial layer degeneration of the abdominal aorta. Complex, complicated, and extremely heterogeneous diseases like dissecting AAAs severely limit our ability to understand it. A thorough understanding of cell types and signaling pathways associated with the initiation and progression of dissecting AAA is essential for the development of medical therapy. Single-cell RNA sequencing (scRNA-seq) was performed on the abdominal aortas from ApoE-/- mice at days 28 post-Angiotensin II-induced mouse dissecting AAAs. According to the Angiotensin II-induced dissecting AAA model described in this study, alterations in cellular subpopulations, fractions, and transcriptome profiles are present. Examination of the transcriptomic profiles of the abdominal aortic single cells from ApoE-/- mice at days 28 post-Angiotensin II-induced mouse dissecting AAAs or normal abdominal aortas.