Transcriptomic profiling of long non-coding RNAs identifies circRmst as a regulator of midbrain dopamine neuron migration [circRMSTKD]

Midbrain dopamine (mDA) neurons play an essential role in cognitive and motor behaviours and are linked to different brain disorders. However, the molecular mechanisms underlying their development, and in particular the role of long non-coding RNAs (lncRNAs), remain incompletely understood. Overall design: To provide experimental evidence for functional roles of circRMST, we investigated the effect of circRmst Knockdown on neuron morphology and neuron migration together with the effect of circRmst KD on gene expression.