Remofuscin induces xenobiotic detoxification via a lysosome-to-nucleus signaling pathway to extend the Caenorhabditis elegans lifespan.

Lipofuscin is known as intracellular waste substance produced by damaged mitochondrial incompleted decomposition. And it is a biomarker of aging. As aging, accumulation of the lipofuscin in retinal pigment epithelium induces blindness called Age-related macular degeneration. Soraprazan is developed to reduce the lipofuscin production and cure the age-related macular degeneration. Soraprazan reducing the age biomarker lipofuscin can be suggested to have effect of longevity extension. C.elegans were treated on NGM agar plate containing 0, 50, 100, 200 M soraprazan and showed the lipofuscin reduction and extension of longevity. To identify the mechanism, 0 and 200 M treated worms RNA expression was analyzed through microarray.脂褐素（Lipofuscin）是由受损线粒体未完全分解产生的细胞内代谢废物，同时也是衰老的生物标志物。随着机体衰老，脂褐素在视网膜色素上皮（retinal pigment epithelium）中的积累会引发名为年龄相关性黄斑变性（Age-related macular degeneration）的致盲病症。索拉赞（Soraprazan）的研发旨在减少脂褐素生成并治疗年龄相关性黄斑变性。鉴于索拉赞能够降低衰老生物标志物脂褐素的水平，其被认为具备延长寿命的潜在功效。研究人员将秀丽隐杆线虫（C.elegans）接种于含0、50、100、200 M索拉赞的NGM琼脂平板（NGM agar plate）上培养，结果显示受试线虫体内脂褐素水平降低且寿命得以延长。为探明其作用机制，研究人员通过基因芯片（microarray）技术对经0 M与200 M索拉赞处理的线虫进行了RNA表达谱分析。