Estimated prevalence (probability) of genetic susceptibility in different geographic regions.

‡Per 105 population. The prevalence of MS in each region is from data provided in Reference [33]. A range is given because, often, a range of estimates are available for a particular region.*Studies [11]–[13] reported pair-wise MZ-twin concordance-rates, which have been converted into proband-wise rates assuming a random sampling of twin-pairs [30]. Study [12], however, reported no double ascertainment of twin-pairs and, therefore, almost certainly violates this assumption [30].†P(G) calculated according to Eq. (6); Prop. (4.2a); Appendix S1 (Section C); that: This equation assumes that (g) for each geographic region is: ; Appendix S1; Section C; Prop. (5.2b)Moreover, as noted in Prop. (4.2b), Eq. (6) also assumes that: A narrower range-estimate could be provided by Eq. (13); Prop. (4.2b) of Appendix S1 (Section C) . However, regardless of which range-estimate for (zmax) is used, this only impacts the lower-bound estimates for P(G). The upper-bound estimates remain the same.