NetPath

This repository is no longer available. NetPath is currently one of the largest open-source repository of human signaling pathways that is all set to become a community standard to meet the challenges in functional genomics and systems biology. Signaling networks are the key to deciphering many of the complex networks that govern the machinery inside the cell. Several signaling molecules play an important role in disease processes that are a direct result of their altered functioning and are now recognized as potential therapeutic targets. Understanding how to restore the proper functioning of these pathways that have become deregulated in disease, is needed for accelerating biomedical research. This resource is aimed at demystifying the biological pathways and highlights the key relationships and connections between them. Apart from this, pathways provide a way of reducing the dimensionality of high throughput data, by grouping thousands of genes, proteins and metabolites at functional level into just several hundreds of pathways for an experiment. Identifying the active pathways that differ between two conditions can have more explanatory power than just a simple list of differentially expressed genes and proteins.

本仓库现已不再可用。NetPath 目前是最大的开源人类信号通路数据库之一，并正逐步成为满足功能基因组学和系统生物学挑战的社区标准。信号网络是解析细胞内众多复杂调控机制的关键。多种信号分子在疾病过程中发挥着至关重要的作用，其功能的改变直接导致疾病的发生，并已被视为潜在的药物靶点。了解如何恢复这些因疾病而失调的通路，对于加速生物医学研究至关重要。本资源旨在揭开生物学通路的神秘面纱，并突出了它们之间关键的关系与联系。除此之外，通过将数千个基因、蛋白质和代谢物在功能层面上进行分组，形成仅数百个通路，通路提供了降低高通量数据维度的一种方法。识别两种条件之间差异的活性通路，相较于仅列出差异表达基因和蛋白质的简单列表，具有更强的解释力。