Integrative analysis of array-miRNAs and matched Affymetrix gene expression in esophageal squamous cell carcinoma

ESCC is an aggressive tumor with about less than 20% 5-year survival rate, which is fourth worst among all cancers in the USA and the sixth leading cause of cancer mortality worldwide. miRNAs is an important layer of gene regulation that is able to integrate multiple genes into biologically networks.We previously characterized the profile of mRNA expression in ESCC [GSE44021]. In current study, we focused on the relationship of mRNA and miRNA using results from arrays in 113 cases from a high-risk region of China. In order to study a) differential expressed miRNAs and mRNA involved in the pathogenesis of ESCC; b) miRNA significantly correlates with mRNA expressed within the same ESCC set; c) significant miRNA expressions associate with patients’ clinical parameters including patients survival as a potential prognostic biomarker, we did mRNA arrays and miRNA arrays by using 113 ESCC cases with tumor and matched normal tissues.