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Characterization of a Mycobacterium smegmatis Mutant That Is Simultaneously Resistant to d-Cycloserine and Vancomycin

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PubMed Central2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC89937/
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资源简介:
A mutant of Mycobacterium smegmatis has been isolated that is simultaneously resistant to both d-cycloserine (d-CS) and vancomycin. Genetic complementation with a PBP4 homolog restores sensitivity to both drugs. Resistance to d-CS and vancomycin in this mutant is most likely due to a novel mechanism involving peptidoglycan assembly at the cell surface.
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American Society for Microbiology (ASM)
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