Initial conditions for the structured model comprising metabolic status, growth status and culture conditions for the simulated experiment.

The estimated cultivation history of cells is given below the experiment name.aprecultures were carried out in T-flasks (Cult1, Cult2, Pred.) or roller bottles (Cult3) which caused slight differences in culture conditions and growth status of cells (see Rehberg et al. [23]). Initial values for intracellular metabolite concentrations (metabolic status) are taken from the steady state value of Cult1 at 200 h determined via model simulations.bestimated during model fitting.csee supporting information 4.Initial conditions for the structured model comprising metabolic status, growth status and culture conditions for the simulated experiment.