Mutations found in <i>covS</i> gene of GAS strain 5448/<i>covS</i>⁺ during infection in mice.^a

aPutative domains of CovS as defined elsewhere [8], [11], where mutations occur: CovS: TMI (22–33); EC Loop (34–180); TMII (181–205); HAMP (208–266); HisKA (269–333); HATPase (386–492). bTissue from which clones were obtained. cNucleotide (NT) position of change, or range of change, based on position of the covS start codon. dNumber of nucleotides of WT-covS replaced, inserted, or deleted. eNumber of clones sequenced. fEffect on CovS protein.