Observation of synergistic antibacterial properties of Prodigiosin from Serratia marcescens jx-1 with metal ions in clinical isolates of Staphylococcus aureus

Data showed we obtained clinical isolates of Staphylococcus aureus including Methicillin-resistant S. aureus (MRSA) and Methicillin-sensitive S. aureus (MSSA) strains and evaluated the antibacterial efficacy of prodigiosin alone or in combination with different metal ions on clinical isolates of MRSA and MSSA strains. The results showed the metal ions Cu(II), Al(III), and Zn(II) can inhibit the cell growth of MRSA and MSSA at concentrations between 0.1 mM and 1.5 mM. and we found that also Zn(II) and Al(III) in combination with PG resulted in a significant synergistic antibacterial effect against MRSA and MSSA.

研究表明，我们获得了包括耐甲氧西林金黄色葡萄球菌（MRSA）和甲氧西林敏感金黄色葡萄球菌（MSSA）菌株在内的临床分离株，并评估了紫霉素单独或与不同金属离子联合使用对MRSA和MSSA菌株的抗菌活性。研究结果显示，铜离子Cu(II)、铝离子Al(III)和锌离子Zn(II)在0.1 mM至1.5 mM的浓度范围内能够抑制MRSA和MSSA菌株的细胞生长。此外，我们发现，锌离子Zn(II)和铝离子Al(III)与紫霉素PG的联合使用，对MRSA和MSSA菌株产生了显著的协同抗菌效应。