small RNA seq profile of DG and CA region of mice subjected to 2 or 10 weeks of environmental enrichment and their respective home cage controls

Physical exercise in combination with cognitive training is known to improve memory function and lower the risk for various complex diseases including Alzheimer's disease. Here we show that prolonged exposure of mice to such an environmental enrichment paradigm mediates long-lasting beneficial effects on memory function and synaptic plasticity even after the end of enrichment training and also provides a cognitive advantage to the offspring. We furthermore show that this effect is mediated via changes in sperm RNA involving the expression of miR-212/132. small RNA profile from adult animals (hippocampal DG or CA region) subjected to 2 weeks or 10 weeks of environmental enrichment已有研究表明，有氧运动与认知训练相结合，可改善记忆功能，并降低包括阿尔茨海默病（Alzheimer's disease）在内的多种复杂疾病的发病风险。本研究发现，小鼠长期暴露于该环境丰富化范式（environmental enrichment paradigm）中，即使在丰富化训练结束后，仍可对记忆功能与突触可塑性（synaptic plasticity）产生持久的有益影响，同时还能为子代带来认知优势。此外，本研究证实该效应是通过精子RNA的变化介导的，其中涉及miR-212/132的表达调控。本数据集包含接受2周或10周环境丰富化训练的成年动物（海马DG区或CA区）的小RNA表达谱（small RNA profile）。