Tat-specific cellular immune responses in subjects with a positive response after immunization with Tat.

The median intensity, with interquartile range of peak of responses, is shown for subjects with at least a positive cellular response at any given time point after the first immunization and up to week 48. Pre-post vaccination median change was evaluated by the Wilcoxon signed-rank test. IFN-γ, IL-2, IL-4 production by PBMC and CD4+ or CD8+ lymphoproliferative responses were measured at baseline and up to week 48 after the first immunization. Results are stratified by Tat doses, (7.5 and 30 µg). n indicates the number of responders. aMedian (interquartile range) of peak of responses, weeks 8, 12, 20, 48. bTotal subject tested for cytokines: 35; for proliferation: 31. cTotal subjects tested for proliferation: 33; for proliferation: 31. *P<0.05, ** P<0.01.