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FRA1 controls acinar cell plasticity during murine KrasG12D-induced pancreatic acinar to ductal metaplasia

NIAID Data Ecosystem2026-05-02 收录

癌前病变机制

细胞可塑性调控

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE235543 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2024-09-06

癌前病变机制

肿瘤微环境

Background: Pancreatic ductal adenocarcinomas (PDACs) are highly lethal and aggressive with oncogenic KRAS being the main oncogenic driver of the disease. PDACs have been extensively profiled at advan

NIAID Data Ecosystem40

mRNA expression pattern of KrasG12D mice with acute pancreatitis compared with wild-type mice without acute pancreatitis. Mus musculus

癌前病变机制

转基因小鼠模型转录组学

Transgenic KrasG12D mice can recapitulate pancreas intra-epithelial neoplasia (PanIN). Caerulein is a cholecystokinin analogue and induces acute pancreatitis when injected intra-abdominally. Caerulein

NIAID Data Ecosystem40

ER-phagy and proteostasis defects create a pre-malignant injury state in Kras-mediated tumourigenesis (RNA-Seq)

癌前病变机制

内质网自噬(ER-phagy)

Pancreatic acinar cells are surprisingly resistant to pre-malignant transformation by the mutant Kras oncogene. Here, reporter mice show that an early, transcriptionally-mediated effect of Kras activa

NIAID Data Ecosystem20

Loss of ∆Np63 induces epigenetic rewiring and enhances plasticity towards alveolar identity

表观遗传重编程

细胞可塑性调控

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

NIAID Data Ecosystem40

Stem cell-like properties of CK2β-downregulated mammary cells [mRNA]. Homo sapiens

癌细胞机制

细胞可塑性调控

The ubiquitous Protein kinase CK2 has been demonstrated to be overexpressed in a number of human tumors. This enzyme is composed of two catalytic α or α’ subunits and a dimer of β regulatory subunits

NIAID Data Ecosystem40

FRA1 controls acinar cell plasticity during murine KrasG12D-induced pancreatic acinar to ductal metaplasia

资源简介：

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