Investigation of carbon source metabolism on transcriptome of clinical S. pneumoniae isolates

The goal of this study was to investigate the transcriptome of clinical S. pneumoniae isolates after growth in chemically defined medium, supplemented with four different carbon sources. We aimed to look for gene expression changes when comparing glucose grown bacteria to the other three nasopharynx carbon sources. This study provided more insights into the carbon source metabolism of S. pneumoniae, related to the corresponding transcriptome and will help to understand more the prerequisites necessary for S. pneumoniae to become a successful colonizer of the host nasopharynx.