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Polymyxin analogues collected from ChEMBL and literature
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创建时间:
2023-01-25
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Binding affinity (kcal/mol) and nonbonding interactions of donepezil and its designed analogues.
Binding affinity (kcal/mol) and nonbonding interactions of donepezil and its designed analogues.
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HTS Cluster 1 and Singleton hits.
1As of 09/03/09. Number of bioassays in which the compound was tested/number in which the compound was active/number in which the compound has been confirmed as an inhibitor.
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R-group replacement resource
A database with R-groups frequently used in medicinal chemistry and their preferred replacements is provided. For frequently used R-groups, replacements are organized in hierarches as specified in the
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Total Synthesis of Salimabromide: A Tetracyclic Polyketide from a Marine Myxobacterium
Salimabromide is an antibiotic polyketide that was previously isolated from the obligate marine myxobacterium Enhygromyxa salina, and its densely functionalized and conformationally rigid tetracyclic
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Approach to Monobactams and Nocardicins via Diastereoselective Kinugasa Reaction
A Kinugasa reaction between copper(I) acetylides and cyclic nitrones derived from chiral amino alcohols and glyoxylic acid is reported. The stereochemical preferences observed in this reaction are di
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