Assembly of a Key Dienic Intermediate for Tetrodotoxin via a Machetti–DeSarlo Reaction
收藏数据链接：
官方服务：
资源简介：
A route to a racemic diene intermediate for the synthesis of tetrodotoxin is described. Key steps of the sequence leading to such a compound include the oxidative amidation of a phenol, a Cu(II)-catalyzed cyclocondensation of a nitroketone with an olefin (Machetti–DeSarlo reaction), and a nucleophilic fragmentation of the resulting isoxazoline. Several unusual reactions encountered in the course of this study are thoroughly discussed.
创建时间：
2016-02-18
