Transcription factors (TF) significantly connected to 198 genes in the “TNFα profile”.

Method: The genes in the “TNFα profile” were used to query to search an interaction database of 22651 genes to ask if the genes in the query are significantly regulated by transcription factors. Significantly over-connected transcription factors have a z-score of >0 with the p value dependent on the size of the dataset.
aActual: number of genes in TNF profile regulated by the chosen TF; R: number of genes in the complete database regulated by the chosen TF. bExpected: mean value for hypergeometric distribution (n*R/N). cRatio: connectivity ratio (Actual/Expected). dp-value: probability to have the given value of Actual or higher (or lower for negative z-score). ez-score: z-score ((Actual-Expected)/sqrt(variance)).