Clustering (<i>C</i>), characteristic path length (<i>L</i>), modularity (<i>Q</i>), global efficiency (<i>E_glob</i>), local efficiency (<i>E_loc</i>) and small-worldness () parameters obtained for the brain anatomical networks of control and shiverer mice groups.

For each measure and fiber tracking algorithm, mean values are reported with their corresponding standard errors (i.e. the uncertainty of how the sample mean represents the underlying population mean). For each measure, the multivariate permutation P-value corresponds to the null hypothesis that means of obtained group values are equal (a P-value near to zero, i.e. P<0.05, indicates a significant difference between groups). The small P-values obtained for measures C, Q, Eglob, Eloc and (all P<0.0324) indicates a significant decreases on the shiverer subjects of these structural network attributes, which in conjunction with the significant increase of measure L (P<0.05) reflects a considerable reduction in the amount of possible nervous information that can be exchanged over the brain and how deficiently and no optimally it can be managed. For obtained gamma () and lambda () parameters, and their influence on the index, please see Table S2. Significant P values are depicted in bold type.