The RFX transcription factor gene, daf-19, has dual funcitons in ciliated and non-ciliated neurons. Caenorhabditis elegans

Cilia are required for many sensory and motility related functions and are involved in growing number of genetic disorders termed ciliopathies. DAF-19, RFX type transcription factor controls expression of many cilia structure and function related genes. To this end, transcriptional profiling of daf-19 mutants (which do not form cilia) and wild-type animals was performed using selectively staged larval stages where cilia mature and maintained, structurally as well as functionally. Overall design: We used microarray based expression analysis to detail expression control exerted by DAF-19 at various stages of life cycle