Effect of CXCR2 knockout on gene expression of BRAFV600E/PTEN-/- mice

To elucidate the mechanism by which CXCR2 perturbation in melanocytes could alter initiation and growth of BrafV600E/Pten-/- melanoma, we examined the transcriptome of tumors arising in BrafV600E/Pten-/-/Cxcr2WT (n=7) and BRAFV600E/PTEN-/-/CXCR2-/- (n=8) mice. Comparative gene expression profiling analysis of RNA-seq data between BRAFV600E/PTEN-/-/CXCR2-/- and BrafV600E/Pten-/-/Cxcr2WT mice.