Cryo-EM structure of DNMT3A1 UDR in complex with H2AK119Ub-nucleosome
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Cryo-EM structure of DNMT3A1 UDR in complex with H2AK119Ub-nucleosome Descriptor: DNA (146-MER), DNA (cytosine-5)-methyltransferase 3A, Histone H2A, ... Authors: Gretarsson, K, Abini-Agbomson, S, Armache, K.-J, Lu, C. Deposit date: 2023-11-05 Release date: 2024-09-11 Last modified: 2025-05-21 Method: ELECTRON MICROSCOPY (2.88 Å) Cite: Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch. Sci Adv, 10, 2024
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2023-11-05
