The genomic region (~4 Mb) of the human major histocompatibility complex (MHC) on chromosome 6p21 is a prime model for the study and understanding of conserved polymorphic sequences (CPSs) and structu

NIAID Data Ecosystem60

Senataxin and RNase H2 act redundantly to suppress genome instability during class switch recombination

免疫基因组学

DNA修复

Class switch recombination generates antibody distinct isotypes critical to a robust adaptive immune system and defects are associated with auto-immune disorders and lymphomagenesis. Transcription is

NIAID Data Ecosystem50

Table3_Integration of single-cell and bulk RNA-seq to establish a predictive signature based on the differentiation trajectory of M2 macrophages in lung adenocarcinoma.XLSX

癌症预后模型

巨噬细胞分化

Background: Tumor-associated macrophages as important members of the tumor microenvironment, are highly plastic and heterogeneous. TAMs can be classified into two preliminary subtypes: M1 and M2 macro

NIAID Data Ecosystem70

Table_2_A Novel Signature of 23 Immunity-Related Gene Pairs Is Prognostic of Cutaneous Melanoma.docx

皮肤黑色素瘤

免疫基因组学

In this study, we aimed to identify an immune-related signature for predicting prognosis in cutaneous melanoma (CM). Sample data from The Cancer Genome Atlas (TCGA; n = 460) were used to develop a pro

NIAID Data Ecosystem50

Functional specialization of human tonsil macrophages is controlled by both ontogeny and niche-derived signals

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