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Secreted Frizzled-Related Protein 5 is Downregulated in Obesity and Promotes ?-Cell Proliferation

ChEBI2014-10-10 更新2026-07-21 收录

肥胖相关蛋白功能

β细胞增殖

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-44047 数据链接链接失效反馈

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Secreted Frizzled-Related Protein 5 is Downregulated in Obesity and Promotes ?-Cell Proliferation

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创建时间：

2014-10-10

β细胞增殖

肥胖诱导2型糖尿病

Comparison of gene expression in pancreatic islets of BTBR-ob/ob mouse model of obesity-induced type 2 diabetes, and in non-diabetic control mice, B6-ob/ob identified Asf1b as an important gene candid

NIAID Data Ecosystem70

Mus musculus Raw sequence reads. Mus musculus

β细胞增殖

转录组学分析

We have constructed a model to induce the proliferation of pancreatic beta cells by a short-term high-fat diet and attempted to explore the underlying mechanism by transcriptomics.

NIAID Data Ecosystem30

Stimulation of Human and Rat Islet β-Cell Proliferation with Retention of Function by Nkx6.1. Rattus norvegicus

β细胞增殖

糖尿病治疗

The homeodomain transcription factor Nkx6.1 plays an important role in pancreatic islet β-cell development, but its effects on adult β-cell function, survival, and proliferation are not well understoo

NIAID Data Ecosystem20

Effect of glucose on recruitment of beta cells into DNA-synthesis and on cell cycle re-entry of previously recruited cells.

β细胞增殖

葡萄糖调控细胞周期

Adult (8-week-old; n = 5) and neonatal (2–3 days-old; n = 3) beta cells were cultured at the indicated glucose concentrations for 10 days with sequential labeling with EdU (day 3 to day 6) and BrdU (d

NIAID Data Ecosystem50

RNA sequencing discerns sub-populations of pancreatic Ã-cells and dynamics of gene expression in partial pancreatectomy model

单细胞转录组学

β细胞增殖

We employed single-cell RNA sequencing of islets in young mice subjected to partial pancreatectomy (PPTx). Four clusters of pancreatic beta cells including a subpopulation of replicating beta cells. P

NIAID Data Ecosystem20

Secreted Frizzled-Related Protein 5 is Downregulated in Obesity and Promotes ?-Cell Proliferation

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