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Tuning of Copper-Catalyzed Multicomponent Reactions toward 3‑Functionalized Oxindoles

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Figshare2016-05-16 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Tuning_of_Copper_Catalyzed_Multicomponent_Reactions_toward_3_Functionalized_Oxindoles/3249778
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A tunable copper-catalyzed azide–alkyne cycloaddition (CuAAC)-initiated multicomponent reaction strategy for the construction of 3-functionalized indolin-2-ones is reported. Upon controlling the ring opening of four-membered O-heterocyclic intermediates, this unique method enables the divergent derivatization of N-protected isatins to give three-component (3-CR) and four-component (4-CR) adducts, respectively.
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2016-05-16
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