GI tract hyperplasia at 7 and 14 days after radiation treatment.

Note: H&E stained tissues were observed under a microscope with 100× magnification. Villous length and crypt depth was measured, no. of crypt branching were calculated in ten random fields. Data are expressed as Mean±SD. For villous length, two way ANOVA showed significant interactions over time between treatments in jejunum and ileum (all p<0.01), no interaction over time between treatments in duodenum (p = 0.058). No differences were detected between PC61+irradiation compared to Rat IgG+irradiation treatment groups (p≥0.059). No significant differences were found between groups treated with PC61+sham irradiation compared to Rat IgG+sham irradiation (all p>0.05). Differences between all other pair-wise comparisons of treatment group profile over time were significant (p<0.05). For crypt depth, two way ANOVA showed no interactions over time between treatments (p≥0.108). No differences were detected between PC61+irradiation compared to Rat IgG+irradiation treatment groups (p≥0.174). No significant differences were found between groups treated with PC61+sham irradiation compared to Rat IgG+sham irradiation (all p>0.05). Differences between all other pair-wise comparisons of treatment group profile over time were significant (p<0.05). For crypt branching, two way ANOVA showed significant interactions over time between treatments (p<0.05), no interactions over time between treatments in duodenum (p = 0.868) and jejunum (p = 0.463). No differences were detected between PC61+irradiation compared to Rat IgG+irradiation treatment groups (p≥0.249). No significant differences were found between groups treated with PC61+sham irradiation compared to Rat IgG+sham irradiation (all p>0.05). Differences between all other pair-wise comparisons of treatment group profile over time were significant (p<0.05). All post hoc pairwise comparisons were performed with Tukey's multiple comparisons.