Bubble Sweeping Nanomotors for Acute Kidney Injury Therapy

Acute
kidney injury (AKI) causes renal ischemic injury and severe
damage to the ultrastructure, metabolism, function, and electrophysiology
of renal tissue. Here, we report a precision treatment strategy for
enhancing antioxidative stress properties, inhibiting ferroptosis,
and regulating mechanical stress to protect kidney tissue to eliminate
injury via the use of Pt and hyaluronic-acid-modified bovine serum
albumin with cerium dioxide loading. In the AKI microenvironment,
Pt catalyzes H2O2 to produce O2,
which reduces cellular hypoxia. The nanoparticles release CeO2, which can restrain oxygen free radical damage, resulting
in massive ROS elimination. Interestingly, the combination of CeO2 and O2 can alleviate ferroptosis and ameliorate
mechanical stress. Moreover, O2 induces the shuttling of
nanoparticles in the AKI region. These findings show that this nanomedicine
system can precisely protect against AKI by reducing oxidative damage,
downregulating ferroptosis, and ameliorating mechanical stress and
is a promising candidate active drug delivery system for AKI treatment.