Genome wide histone modification and RNA Polymerase II maps of K562 cell line

Transcription unit identification is one of the most fundamental yet challenging problems in bioinformatics, due to the inherent value protein-coding genes and regulatory role of non-coding RNAs such as microRNA for functional analysis. In recent years, histone modifications have been found to correlate with transcription. Some histone modifications like H3K4me3 and H3K27ac are highly enriched at transcription start site while other histone modifications like H3K36me3 are highly enriched in actively transcribed regions. On the contrary, histone modifications, like H3K9me3 and H3K27me3,are highly enriched in repressed regions. Therefore, it seems possible to identify transcription units using histone modifications. Here, we report genome-wide paired-end ChIP-seq profiles of core histone modifications (H3K4me3, H3K27ac, H3K4me1, H3K36me3, H3K27me3, H3K9me3) and RNA Polymerase II that was used to identify genome-wide transcription units in K562. Pubmed ID: 32264931